| S-MIME | Secure MIME |
| S/N | Signal to Noise Ratio |
| S/PDIF | Sony/Philips Digital Interface |
| S | Sulfur |
| SA | Surface area; Subresolution assist; Structured analysis |
| S/A | Sensor/actuator |
| SAA | Static automated analysis |
| SAB | Sensor/actuator bus |
| SACD | Super Audio CD |
| SAD | Selected Area Diffraction |
| SAE | Society of Automotive Engineers |
| SAED | Selected Area Electron Diffraction |
| SAGA | Standards und Architekturen für e-Government Anwendungen |
| SAM | Scanning Auger Microscopy |
| SAN | Storage Area Network |
| SANS | Small Angle Neutron Scattering |
| SAR | Successive Approximation Register |
| SARE | Segmentation And Reassembly Element |
| SAT | Spray acid tool |
| SAW | Surface-acoustic wave |
| SAX | Simple API for XML |
| SAXS | Small Angle X-ray Scattering |
| Sb | Antimony |
| SB | Strong base ion exchange |
| SBC | S Bus Circuit |
| SBC-X | S Bus Circuit Extended |
| SBD | Schottky Barrier Diode |
| SBL | Scanned Beam Laminography |
| SBT | Slender Body Theory |
| SBU | Sequential build-up |
| Sc | Scandium |
| SC | Semi-Conducting |
| SC1 | Standard Clean 1 |
| SC2 | Standard Clean 2 |
| SCA | Surface charge analysis |
| SCALPEL | Scattering with Angular Limitation in Projection Electron-beam Lithography |
| SCART | European connector definition for TVs and VCRs |
| SCBA | Self-contained breathing apparatus |
| SCC | Strategic cell controller |
| SCCS | Source code control system |
| SCE | Saturated calomel electrode |
| SCF | Super critical fluid |
| SCI | Surface charge imaging |
| SCIC | Semiconductor integrated circuit |
| SCM | Scanning capacitance microscopy |
| SCNT | Single Chip Network Termination |
| SCP | Single chip package |
| SCR | Silicon controlled rectifier |
| SCS | Single Crystal Silicon |
| SCSI | Small Computer System Interface (pronounced 'sku-zi') |
| SCT | SciTex continuous tone image format |
| SCTE | Society of Telecommunications Engineers |
| SD | Small dual in-line package; structured design; single density |
| S/D | Source/drain |
| SDFL | Schottky-diode FET logic |
| SDH | Synchronous Digital Hierarchy |
| SDHT | Selectively Doped Heterojunction Transistor; SDH/SONET Transceiver |
| SDHT | Selectively Doped Heterojunction Transistor; SDH/SONET Transceiver |
| SDLC | Synchronous data link control |
| SDLTS | Scanning Deep-Level Transient Spectroscopy |
| SDM | Specific Device Model for SAB |
| SDMI | Secure Digital Music Initiative |
| SDR | Software Defined Radio |
| SDRAM | Synchronous Dynamic Random Access Memory |
| SDS | Smart distributed system |
| SDSI | Synchronous data-link control |
| Se | Selenium |
| SE | Spectroscopic ellipsometry; secondary electron; Seed End; Surface Element |
| SEAJ | Semiconductor Equipment Association of Japan |
| SEC | Size exclusion chromatography; Solvent extract conductivity |
| SECAM | Systeme èn Coleur Avec Mémoire (european TV system) |
| SECS | Semiconductor Equipment Communications Standard |
| SEDOR | Spin Echo DOuble Resonance |
| SEG | Selective epitaxial growth |
| SEIM | Software engineering improvement method |
| SEL | Surface Emitting Laser |
| SEM | Scanning electron microscopy; specific equipment model; Standard electronic module |
| SEMI | Semiconductor Equipment and Materials International |
| SEMISPIN | Semiconductor Software Process Improvement Network |
| SEP | Software engineering process |
| SEPG | Software Engineering Process Group |
| SEQDB | Semiconductor Equipment Database |
| SERA | Sequential Electrochemical Reduction Analysis |
| SERDES | Serialization/Deserialization |
| SES | Secondary Electron Spectroscopy |
| SET | Single Electron Tunneling/TransPort |
| SETEC | Semiconductor Equipment Technology Center |
| SEXAFS | Surface Extended X-ray Absorption Fine Structure |
| SF | Super Fluorescence |
| SFB | Symmetry Breaking Force |
| SFC | Supercritical fluid chromatography |
| SFCS | Shop floor control system |
| SFCSI/F | Shop floor control system interface |
| SFD | Stacking Fault Density |
| SFG | Sum Frequency Generation |
| SFM | Surface feet per minute |
| SFTPS | Secure File Transfer Protocol |
| Sg | Seaborgium |
| SGML | Standard Generalized Markup Language |
| SGMM | Semiconductor Generic Manufacturing Model |
| SGMRS | Semiconductor Generic Manufacturing Requirements Specification |
| SGRAM | Synchronous Graphics Random Access Memory |
| SGV | Scalable Vector Graphics |
| SHA | Secure Hash Algorithm |
| SHAC | Simple Hands-free Add-on Circuit |
| SHARC | Super Harvard Architecture Computer |
| SHESQUID | SQUID of brand "SHE" |
| SHF | Super HyperFine (interaction) |
| SHG | Second Harmonic Generation |
| Si | Silicon |
| SI | Semi-Insulating; Service Information |
| SIA | Semiconductor Industry Association |
| SiC | Silicon Carbide |
| SICAT | Siemens Concept Analog Telephone |
| SICOFI | Signalling Codec Filter |
| SICOFI | Signalling Codec Filter |
| SIDP | Sputter ion depth profiling |
| SiGe | Silicon Germanium |
| SiH4 | Silane |
| SIL | Systems Integration Lab (was ATF) |
| SIMO | Single input, multi output |
| SIMOX | Separation by implantation of oxygen |
| SIMS | Secondary Ion Mass Spectroscopy |
| SIO | Serial Input Output |
| SIOA | Surface Induced Optical Anisotropy |
| SIP | Single Inline Package; Session Initiation Protocol |
| SIPO | Serial In Parallel output |
| SIR | Surface Insulation Resistance |
| SIRIJ | Semiconductor Industry Research Institute of Japan |
| SISFET | Semiconductor-Insulator-Semiconductor FET |
| SISO | Single input, single output; Serial in serial out |
| SIV | Sensors in vacuum |
| SL | Specification limit; Super lattice |
| SLAC | Subscriber Line Audio processing interface |
| SLAM | Scanning laser acoustic microscopy; Single layer alumina metallization |
| SLC | Surface laminar circuit |
| SLD | Strong Lattice Deformation |
| SLEED | Spin-Polarized Low Energy Electron Diffraction (aka SPLEED) |
| SLIC | Standard-function Linear Integrated Circuit; Subscriber Line Interface Circuit |
| SLICOFI | Subscriber Line Interface Circuit and Signaling Codec Filter |
| SLIP | Single Line Internet Protocol |
| SLM | Spatial Light Modulator |
| SLOC | Source lines of code |
| SLPSS | Semiconductor Laser Pumped Solid State (laser source) |
| SLR | Small Lattice Relaxation |
| SLS | Strained Layer SL |
| SLSI | Super large scale integration |
| Sm | Samarium |
| SM | Stress migration; Surface mount |
| SMA | Shape Memory Alloy; Surface mount assembly |
| SMB | Single-mask bumping |
| SMC | Surface-mounted components |
| SMD | Surface Mount Devices |
| SME | Subject matter expert; Software maintenance engineer |
| SMEMA | Surface Mount Equipment Manufacturers Association |
| SMG | Screen management guide |
| SMID | Single Instruction Multiple Data |
| SMIF | Standard mechanical interface |
| SMIL | Synchronized Multi-media Integration Language |
| SMOBC | Solder mask over bare copper |
| SMPM | SECS message protocol machine |
| SMPTE | Society of Motion Picture and Television Engineers |
| SMR | Semiconductor mask representation |
| SMS | SECS message service; Short Messaging Service |
| SMSC | Short Message Switching Center |
| SMT | Surface Mount Technology |
| SMTA | Surface Mount Technology Association |
| SMTP | Simple Mail Transfer Protocol |
| SMTS | Strategic Material Transport System |
| Sn | Tin |
| S/N | Signal-to-noise; Serial number |
| SNA | Systems Network Architecture |
| SNAP | Selective Niobium Anodization Process |
| SNAP | Selective Niobium Anodization Process |
| SNMP | Simple Network Managament Protocol |
| SNMS | Sputtered neutral mass spectroscopy |
| SNOM | Scanning nearfield optical microscopy |
| SNR | Signal-to-noise ratio |
| SO | Small outline (package) |
| SOAP | Simple Object Access Protocol |
| SOC | System on (a) Chip |
| SOD | Spin-on-dielectric; Silicon on diamond; Small outline diode |
| SO DIMM | Small Outline Dual-In-line Memory Module |
| SOG | Spin-on glass |
| SOI | Silicon On Insulator |
| SOIC | Small outline IC |
| SOM | Scanning optical microscopy; sulfuric acid-ozone mixture |
| SONET | Synchronous Optical NETwork |
| SOP | Standard operating procedure; Small outline package |
| SOS | Silicon on sapphire |
| SOT | Small outline transistor |
| SOW | Statement of work |
| SP | Simple Profile |
| SPA-LEED | Spot Profile Analysis Low Energy Electron Diffraction |
| SPC | Statistical process control; Surface Photoconductivity |
| SPDE | Service Provider Delivery Environment |
| SPEG | Solid Phase Epitaxy Growth |
| SPGA | Staggered Pin Grid Array; System Programmable Gate Array |
| SPI | Software Process Improvement; Serial-peripheral interface protocol |
| SPICE | Simulation program with integrated circuit emphasis |
| SPIDER-ME | MSPIDER-Manufacturing Equipment Monitor |
| SPIN | Software Process Improvement Network |
| SPLD | Simple Programmable Logic Device |
| SPLICS | Special-Purpose Linear Integrated Circuits |
| SPM | Scanning probe microscopy |
| SportsML | Sports Mark-up Language |
| SPP | Single-phase printing |
| SPR | Semiconductor process representation |
| SPS | Surface preparation system |
| SPST | Single pole, single throw |
| SPT | Shortest processing time |
| SPTS | Simple Program Transport Stream |
| SPV | Surface Photovoltage Spectroscopy |
| SQC | Statistical quality control |
| SQUID | Super conducting QUantum Interference Device |
| SQL | Structured Query Language |
| SQM | System Quality Manager |
| SQPMM | Software Quality and Process Maturity Model |
| Sr | Strontium |
| SR | Shift register |
| SRAC | Supplier Relations Action Council |
| SRAM | Static random access memory |
| SRC | Semiconductor Research Corporation |
| SRP | Spreading resistance probe |
| SRPT | Shortest remaining processing time |
| SRS | Software requirements specification |
| SS | Single sided |
| SSA | Semiconductor Industry Association |
| SSB | Single Side Band |
| SSC | Standard Speech Circuit |